| Pair Name | Lycopene, Eicosapentaenoic acid | ||
| Phytochemical Name | Lycopene (PubChem CID: 446925 ) | ||
| Anticancer drug Name | Eicosapentaenoic acid (PubChem CID: 446284 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Lycopene, Eicosapentaenoic acid | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Up-regulation | Expression | FAS | hsa355 | |
| Down-regulation | Phosphorylation | MTOR | hsa2475 | |
| In Vitro Model | HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 |
| Result | Our novel findings suggest that lycopene and EPA synergistically inhibited the growth of human colon cancer HT-29 cells even at low concentration. The inhibitory effects of lycopene and EPA on cell proliferation of human colon cancer HT-29 cells were, in part, associated with the down-regulation of the PI-3K/Akt/mTOR signaling pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells. J Nutr Biochem. 2009 Jun;20(6):426-34. doi: 10.1016/j.jnutbio.2008.05.001. | Click |
